Abbas Mirshafiey Selected Research

guluronic acid

1/2022	The Evaluation of Safety Property and Apoptotic Efficacy of α-L-Guluronic Acid (G2013), as a Novel NSAID, Under In Vitro Examination on L929 and Hepatocellular Carcinoma Cell Lines.
1/2022	Evaluation of G2013 (α-L-guluronic acid) efficacy on PC-3 cells through inhibiting the expression of inflammatory factors.
10/2021	The effects of guluronic acid (G2013), a new emerging treatment, on inflammatory factors in nonalcoholic steatohepatitis patients under in vitro conditions.
1/2021	Evaluation of the oral administration of α-l-guluronic acid on COX-1 and COX-2 gene expression profile in ankylosing spondylitis patients.
4/2020	The Effects of G2013 (α-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy.
2/2020	Effects of guluronic acid, as a new NSAID with immunomodulatory properties on IL-17, RORγt, IL-4 and GATA-3 gene expression in rheumatoid arthritis patients.
12/2019	Effects of guluronic acid (G2013) on gene expression of TLR2, TLR4, MyD88, TNF-α and CD52 in multiple sclerosis under in vitro conditions.
11/2019	Effect of Guluronic Acid (G2013), As a New Anti-inflammatory Drug on Gene Expression of Pro-inflammatory and Anti-inflammatory Cytokines and Their Transcription Factors in Rheumatoid Arthritis Patients.
6/2019	The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial.
2/2019	A randomized clinical trial for the assessment of the efficacy and safety of guluronic acid (G2013) in patients with rheumatoid arthritis.

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Abbas Mirshafiey Research Topics

Disease

38	Multiple Sclerosis 04/2022 - 01/2005
30	Rheumatoid Arthritis 02/2022 - 01/2005
20	Inflammation (Inflammations) 01/2022 - 07/2005
17	Neoplasms (Cancer) 01/2022 - 10/2004
10	Ankylosing Spondylitis 01/2021 - 06/2015
10	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 06/2019 - 01/2005
9	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 01/2005
8	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 09/2012
6	Pain (Aches) 01/2021 - 03/2013
6	Breast Neoplasms (Breast Cancer) 07/2019 - 04/2015
6	Proteinuria 10/2015 - 08/2002
5	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2017 - 07/2007
4	Body Weight (Weight, Body) 01/2022 - 01/2015
4	Neoplasm Metastasis (Metastasis) 01/2022 - 10/2007
4	Infections 01/2021 - 01/2013
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/2020 - 10/2017
4	Relapsing-Remitting Multiple Sclerosis 01/2018 - 01/2014
4	Glomerulonephritis 01/2015 - 06/2005
4	Edema (Dropsy) 03/2014 - 01/2005
3	Common Variable Immunodeficiency 12/2019 - 01/2016
3	Rheumatic Diseases (Rheumatism) 02/2019 - 08/2005
3	Communicable Diseases (Infectious Diseases) 02/2017 - 10/2007
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 09/2016 - 04/2014
3	Fibrosarcoma 01/2014 - 10/2004
3	Asthma (Bronchial Asthma) 10/2012 - 12/2008
3	Nephrosis 08/2005 - 08/2002
2	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 08/2021
2	Neuroinflammatory Diseases 10/2021 - 09/2010
2	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2021 - 08/2009
2	Atherosclerosis 11/2020 - 04/2018
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2020 - 06/2015
2	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2020 - 08/2015
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2020 - 01/2019
2	Diabetes Complications 11/2019 - 06/2019
2	Primary Immunodeficiency Diseases 01/2016 - 06/2014
2	Demyelinating Diseases (Demyelinating Disease) 09/2015 - 02/2014
2	Disease Progression 09/2015 - 12/2012
2	Atopic Dermatitis (Atopic Eczema) 08/2015 - 06/2011
2	Arthritis (Polyarthritis) 01/2015 - 12/2008
2	Chronic Granulomatous Disease 06/2014 - 04/2012

Drug/Important Bio-Agent (IBA)

36	mannuronic acidIBA 04/2022 - 01/2005
23	Pharmaceutical PreparationsIBA 04/2022 - 10/2004
20	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2022 - 10/2004
18	guluronic acidIBA 01/2022 - 09/2015
18	CytokinesIBA 12/2021 - 12/2012
15	Therapeutic UsesIBA 10/2019 - 08/2005
8	Interleukin-17 (Interleukin 17)IBA 01/2022 - 10/2017
7	EnzymesIBA 01/2018 - 06/2010
5	Matrix Metalloproteinases (MMPs)IBA 01/2020 - 10/2004
5	Vitamin D FDA LinkGeneric 11/2019 - 04/2016
4	Interleukin-6 (Interleukin 6)IBA 10/2021 - 01/2004
4	Biomarkers (Surrogate Marker)IBA 10/2021 - 02/2016
4	Transcription Factors (Transcription Factor)IBA 06/2020 - 05/2014
4	AntioxidantsIBA 04/2020 - 01/2009
4	Interleukin-4 (Interleukin 4)IBA 02/2020 - 04/2014
4	Blood Glucose (Blood Sugar)IBA 01/2020 - 01/2019
4	Insulin (Novolin)FDA Link 01/2020 - 01/2019
4	AntigensIBA 01/2019 - 04/2014
4	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2019 - 11/2007
4	ProstaglandinsIBA 01/2018 - 12/2010
4	Interleukin-22 (IL-22)IBA 07/2016 - 01/2015
4	Proteins (Proteins, Gene)FDA Link 04/2016 - 01/2013
4	CreatinineIBA 10/2015 - 08/2002
4	LipidsIBA 03/2014 - 07/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2014 - 12/2008
3	ChemokinesIBA 01/2021 - 08/2014
3	Toll-Like Receptors (Toll-Like Receptor)IBA 06/2019 - 01/2016
3	Immunosuppressive Agents (Immunosuppressants)IBA 02/2017 - 06/2005
3	Anti-Citrullinated Protein AntibodiesIBA 01/2017 - 08/2013
3	AntibodiesIBA 12/2016 - 04/2014
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2016 - 04/2012
3	Inosine Triphosphate (ITP)IBA 09/2016 - 04/2014
3	Antigen-Antibody Complex (Immune Complex)IBA 02/2016 - 06/2005
3	Matrix Metalloproteinase 2 (Gelatinase A)IBA 06/2015 - 10/2004
3	AutoantigensIBA 01/2015 - 08/2013
3	LeukotrienesIBA 03/2014 - 06/2010
3	Free RadicalsIBA 01/2014 - 01/2009
3	CholesterolIBA 08/2005 - 08/2002
2	Amyloid beta-PeptidesIBA 01/2022 - 06/2013
2	Interleukin-8 (Interleukin 8)IBA 01/2022 - 01/2020
2	TNF Receptor-Associated Factor 6 (TRAF6)IBA 10/2021 - 06/2020
2	VaccinesIBA 12/2019 - 12/2015
2	NF-kappa B (NF-kB)IBA 11/2019 - 11/2017
2	HexosaminesIBA 11/2019 - 01/2019
2	Toll-Like Receptor 2IBA 06/2019 - 04/2018
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2018 - 01/2018
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2018 - 10/2017
2	Malondialdehyde (Propanedial)IBA 02/2017 - 10/2016
2	Superoxide DismutaseIBA 02/2017 - 10/2016
2	Rheumatoid FactorIBA 01/2017 - 01/2017
2	AlginatesIBA 01/2017 - 06/2005
2	GenisteinIBA 10/2015 - 01/2014
2	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2015 - 01/2004
2	Tyrosine Kinase InhibitorsIBA 07/2014 - 09/2013
2	Imatinib Mesylate (Gleevec)FDA Link 06/2014 - 09/2013
2	Interferon-gamma (Interferon, gamma)IBA 04/2014 - 04/2012

Therapy/Procedure

20	Therapeutics 01/2022 - 08/2002
8	Oral Administration 01/2021 - 04/2015
2	Injections 01/2022 - 04/2020
2	Intravenous Injections 01/2017 - 01/2004